Bruton’s tyrosine kinase (BTK) inhibitors, drugs utilized in cancer, are being repurposed for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) (COVID-19).
Recently, BTK inhibitors acalabrutinib and ibrutinib have been found to protect against pulmonary injury in a small group of patients infected with SARS-CoV-2. The high levels of pro-inflammatory cytokines found in the circulation of COVID-19 patients with severe lung disease suggest the involvement of the innate immune system in this process. Understanding the potential mechanism of action of BTK inhibition in SARS-CoV-2 is clearly of importance to determine how acalabrutinib, ibrutinib and possibly other BTK inhibitors may provide protection against lung injury.
No reliable biological marker for the diagnosis of asthma in younger children is currently available.
The role of capecitabine in neoadjuvant and adjuvant chemotherapy for early-stage triple-negative breast cancer (TNBC) is highly controversial.
Functional changes in peripheral arterial disease (PAD) could play a role in higher cardiovascular risk in these patients.
Extracellular vesicles (EVs) are nano-sized particles secreted by most 
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Skin autofluorescence (SAF) is a non-invasive marker of 
Cellular sex has rarely been considered as a biological variable in preclinical research, even when the pathogenesis of diseases with
Whipple’s disease is a chronic infectious disease caused by the Gram-positive bacterium Tropheryma whipplei (TW), which not only affects the