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Biology research

Cellular sex has rarely been considered as a biological variable in preclinical research, even when the pathogenesis of diseases with predictable sex differences is studied. In this perspective, proteomics, and “omics” approaches in general, can provide powerful tools to obtain comprehensive cellular maps, thus favoring the discovery of still unknown sex-biased physio-pathological mechanisms.

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Our previous study indicated that aerobic exercise relieves cognitive impairment in patients with vascular cognitive impairment (VCI) via regulating brain-derived neurotrophic factor (BDNF), but the mechanism is not yet clear.

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Medical research

  • Utility of basophil activation test for predicting the outcome of wheezing in children: a pilot study +

    Utility of basophil activation test for predicting the outcome of wheezing in children: a pilot study No reliable biological marker for the diagnosis of asthma in younger children is currently available. Read More

  • The role of capecitabine-based neoadjuvant and adjuvant chemotherapy in early-stage triple-negative breast cancer: a systematic review and meta-analysis +

    The role of capecitabine-based neoadjuvant and adjuvant chemotherapy in early-stage triple-negative breast cancer: a systematic review and meta-analysis The role of capecitabine in neoadjuvant and adjuvant chemotherapy for early-stage triple-negative breast cancer (TNBC) is highly controversial. Read More

  • The association between pulse wave analysis, carotid-femoral pulse wave velocity and peripheral arterial disease in patients with ischemic heart disease +

    The association between pulse wave analysis, carotid-femoral pulse wave velocity and peripheral arterial disease in patients with ischemic heart disease Functional changes in peripheral arterial disease (PAD) could play a role in higher cardiovascular risk in these patients. Read More

  • Temperament and character of patients with alcohol toxicity during COVID − 19 pandemic +

    Temperament and character of patients with alcohol toxicity during COVID − 19 pandemic Corona virus epidemic may be acts as a stressor or trauma that affects both physical health and mental health. Read More

  • Small RNA sequencing of extracellular vesicles identifies circulating miRNAs related to inflammation and oxidative stress in HIV patients +

    Small RNA sequencing of extracellular vesicles identifies circulating miRNAs related to inflammation and oxidative stress in HIV patients Extracellular vesicles (EVs) are nano-sized particles secreted by most cells. EVs carry nucleic acids that hold promise as potential biomarkers… Read More

  • Skin manifestations after bariatric surgery +

    Skin manifestations after bariatric surgery Skin signs observed in morbid obesity may change as the weight reduces, especially post-bariatric surgery (BaS). Data concerning the skin… Read More

  • Skin autofluorescence predicts new cardiovascular disease and mortality in people with type 2 diabetes +

    Skin autofluorescence predicts new cardiovascular disease and mortality in people with type 2 diabetes Skin autofluorescence (SAF) is a non-invasive marker of tissue accumulation of advanced glycation endproducts (AGE). Read More

  • Sex-dependent differences in the secretome of human endothelial cells +

    Sex-dependent differences in the secretome of human endothelial cells Cellular sex has rarely been considered as a biological variable in preclinical research, even when the pathogenesis of diseases with… Read More

  • Sex differences and psychological stress: responses to the COVID-19 pandemic in China +

    Sex differences and psychological stress: responses to the COVID-19 pandemic in China About 83,000 COVID-19 patients were confirmed in China up to May 2020. Read More

  • Severe pneumonia in adults caused by Tropheryma whipplei and Candida sp. infection: a 2019 case series +

    Severe pneumonia in adults caused by Tropheryma whipplei and Candida sp. infection: a 2019 case series Whipple’s disease is a chronic infectious disease caused by the Gram-positive bacterium Tropheryma whipplei (TW), which not only affects the… Read More
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